first_imgThe 2nd annual Ballyliffin Coastal Challenge 10 mile event will be launched in The Ballyliffin Lodge next Friday Jan 21st @ 7pm .Again the nominated charity is the Hospice unit in Carndonagh.There is an international dimension to the event this time round with a large group from London travelling to participate. The race this year will be Easter Saturday, April 23. For more details go to their facebook page link below: CHALLENGE LAUNCH was last modified: January 15th, 2011 by gregShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more

Fire damages Habitat for Humanity home

first_imgAn early morning fire on Tuesday left a Salmon Creek Habitat for Humanity home uninhabitable.The fire sparked around 5:45 a.m. in a bathroom on the first floor of the two-story house at 915 N.E. Tenney Road. The house is one of five in Evergreen Habitat for Humanity’s Tenny Commons complex across the street from the Salmon Creek Fred Meyer.Rhonda Parker, who lives in the home, said she had just returned from taking her friend, homeowner Tammy Lacy, to work in Janzten Beach. Parker went into the house and saw the fire was “out of control.”“Something was definitely fueling it,” she said.Firefighters with Clark County Fire District 6 and the Vancouver Fire Department arrived within minutes and found smoke coming from the house. Crews knocked out the fire within five minutes, but it had already caused “considerable damage” to the house, said Fire District 6 Chief Jerry Green.The green home was still standing but charred inside.No one was reported injured.Lacy’s two children, Lashay Wesley, 14, and Tatayana Wesley, 13, were asleep in the house at the time of the fire. Tatayana said she woke up to the smell of smoke and — at first — thought someone had burned something while cooking in the kitchen. When she went downstairs, she saw the bathroom was on fire and left the home with her sister.The family had practiced what to do if there was a fire, Tammy Lacy said. She was glad no one was hurt and that they had working smoke alarms.last_img read more

Researchers discover key aspect in pathogenesis of multiple sclerosis

first_img Source: Reviewed by James Ives, M.Psych. (Editor)Sep 4 2018A team of researchers the University of Zurich and the University Hospital Zurich has shown that in multiple sclerosis, it is not only specific T cells that cause inflammation and lesions in the brain. B cells, a different type of immune cell, also play a role. These cells activate T cells in the blood. This discovery explains how new MS drugs take effect, opening up novel options for treating the disease.Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. The body’s own immune cells attack and damage the layer that surrounds nerve cells in the brain and spinal cord, which affects their ability to communicate with each other. The disease, which affects around 2.5 million people worldwide, is a common cause of disability in young adults and affects women particularly often. MS can lead to severe neurological disabilities such as sensory problems, pain and signs of paralysis.B cells activate T cellsA team led by neurologist Roland Martin and immunologist Mireia Sospedra at the University of Zurich (UZH), the University Hospital Zurich (USZ) and researchers at the Karolinska Institute in Sweden has now discovered a key aspect in the pathogenesis of MS. “We were able to show for the first time that certain B cells – the cells of the immune system that produce antibodies – activate the specific T cells that cause inflammation in the brain and nerve cell lesions,” says Roland Martin, Director of the Clinical Research Priority Program Multiple Sclerosis at UZH.Novel MS drugs attack B cellsUntil recently, MS research had mainly focused on T cells, or T helper cells. They are the immune system’s “guardians”, which for example sound the alarm if the organism is infected with a virus or bacteria. In about one in a 1,000 people, the cells’ ability to distinguish between the body’s own and foreign structures becomes disturbed. The effect of this is that the misguided T cells start to attack the body’s own nerve tissue – the onset of MS. However, the T cells aren’t the sole cause of this. “A class of MS drugs called Rituximab and Ocrelizumab led us to believe that B cells also played an important part in the pathogenesis of the disease,” explains Roland Martin. These drugs eliminate B cells, which very effectively inhibits inflammation of the brain and flare-ups in patients.Related StoriesResearch team to create new technology for tackling concussionStudy provides new insight into longitudinal decline in brain network integrity associated with agingDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustB cells’ “complicity” revealedThe researchers established the role of B cells by using an experimental in-vitro system that allowed blood samples to be analyzed. The blood of people with MS revealed increased levels of activation and cellular division among those T cells attacking the body’s myelin sheaths that surround nerve cells. This was caused by B cells interacting with the T cells. When the B cells were eliminated, the researchers found that it very effectively inhibited the proliferation of T cells. “This means that we can now explain the previously unclear mechanism of these MS drugs,” says Roland Martin.Activated T cells migrate to the brainMoreover, the team also discovered that the activated T cells in the blood notably included those that also occur in the brain in MS patients during flare-ups of the disease. It is suspected that they cause the inflammation. Further studies showed that these T cells recognize the structures of a protein that is produced by the B cells as well as nerve cells in the brain. After being activated in the peripheral blood, the T cells migrate to the brain, where they destroy nerve tissue. “Our findings not only explain how new MS drugs take effect, but also pave the way for novel approaches in basic research and therapy for MS,” concludes Roland Martin.last_img read more

Top stories Miniinterstellar spacecraft a wormy weapon against Crohns and a victory

first_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe This week, Russian internet billionaire Yuri Milner proposed making a genuine journey to the stars: a program to develop a tiny spacecraft, weighing less than a gram, and propel it across nearly 40 trillion kilometers of space to the nearest star to study any planets there. Rather than using fuel, Milner hopes to use powerful Earth-based lasers to give it a boost.Brain implant helps quadriplegic play Guitar HeroAfter Ian Burkhart broke his neck and lost all movement below his shoulders at age 19, his brain still told his hands how to move—but the messages couldn’t get through his severed spinal cord. Now, thanks to recent advances in electrical stimulation technology, Burkhart can once again grasp, pour, swipe a credit card, and even play Guitar Hero. To do so, he uses a microelectrode array that reads his brain’s signals and sends them through wires to a gel sleeve that electronically stimulates his muscles.NASA’s planet hunter safe again, for nowNASA has regained control of its exoplanet discovery satellite Kepler following a fraught few days during which the spacecraft had put itself into a protective “emergency mode.” What went wrong is not yet clear, but on Sunday morning controllers had the spacecraft in a stable state with its communications antenna pointing toward Earth, ready to send data about the hiccup.   Parasitic worms may prevent Crohn’s disease by altering bacterial balanceThe parasitic worms that lurk in some people’s intestines may be revolting, but they seem to forestall Crohn’s disease and other types of inflammatory bowel disease. A new study might explain how, revealing that the worms enable beneficial microbes in the intestines to outcompete bacteria that promote inflammation. The results could lead to new ways of treating gut diseases by mimicking the effects of the parasites. Email Sign up for our daily newsletter Get more great content like this delivered right to you! Countrycenter_img Click to view the privacy policy. Required fields are indicated by an asterisk (*) Humans best computers in atom-snatching gameIn the latest effort to entice ordinary people to do scientific scut work, physicists have enlisted online gamers to figure out the fastest way to pick up and move an atom with a beam of light. Surprisingly, people playing an online game came up with better strategies for moving the atom than a computer algorithm alone—even finding solutions that were faster than what the physicists had assumed was a speed limit set by quantum mechanics itself.Russian billionaire unveils big plan to build tiny interstellar spacecraftlast_img read more