The 2nd annual Ballyliffin Coastal Challenge 10 mile event will be launched in The Ballyliffin Lodge next Friday Jan 21st @ 7pm .Again the nominated charity is the Hospice unit in Carndonagh.There is an international dimension to the event this time round with a large group from London travelling to participate. The race this year will be Easter Saturday, April 23. For more details go to their facebook page link below:http://en-gb.facebook.com/pages/The-Ballyliffin-10mile-Coastal-Challenge-2011/146842005338829BALLYLIFFIN CHALLENGE LAUNCH was last modified: January 15th, 2011 by gregShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)
An early morning fire on Tuesday left a Salmon Creek Habitat for Humanity home uninhabitable.The fire sparked around 5:45 a.m. in a bathroom on the first floor of the two-story house at 915 N.E. Tenney Road. The house is one of five in Evergreen Habitat for Humanity’s Tenny Commons complex across the street from the Salmon Creek Fred Meyer.Rhonda Parker, who lives in the home, said she had just returned from taking her friend, homeowner Tammy Lacy, to work in Janzten Beach. Parker went into the house and saw the fire was “out of control.”“Something was definitely fueling it,” she said.Firefighters with Clark County Fire District 6 and the Vancouver Fire Department arrived within minutes and found smoke coming from the house. Crews knocked out the fire within five minutes, but it had already caused “considerable damage” to the house, said Fire District 6 Chief Jerry Green.The green home was still standing but charred inside.No one was reported injured.Lacy’s two children, Lashay Wesley, 14, and Tatayana Wesley, 13, were asleep in the house at the time of the fire. Tatayana said she woke up to the smell of smoke and — at first — thought someone had burned something while cooking in the kitchen. When she went downstairs, she saw the bathroom was on fire and left the home with her sister.The family had practiced what to do if there was a fire, Tammy Lacy said. She was glad no one was hurt and that they had working smoke alarms.
Source:http://www.media.uzh.ch/en/Press-Releases/2018/Multiple-Sclerosis.html Reviewed by James Ives, M.Psych. (Editor)Sep 4 2018A team of researchers the University of Zurich and the University Hospital Zurich has shown that in multiple sclerosis, it is not only specific T cells that cause inflammation and lesions in the brain. B cells, a different type of immune cell, also play a role. These cells activate T cells in the blood. This discovery explains how new MS drugs take effect, opening up novel options for treating the disease.Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. The body’s own immune cells attack and damage the layer that surrounds nerve cells in the brain and spinal cord, which affects their ability to communicate with each other. The disease, which affects around 2.5 million people worldwide, is a common cause of disability in young adults and affects women particularly often. MS can lead to severe neurological disabilities such as sensory problems, pain and signs of paralysis.B cells activate T cellsA team led by neurologist Roland Martin and immunologist Mireia Sospedra at the University of Zurich (UZH), the University Hospital Zurich (USZ) and researchers at the Karolinska Institute in Sweden has now discovered a key aspect in the pathogenesis of MS. “We were able to show for the first time that certain B cells – the cells of the immune system that produce antibodies – activate the specific T cells that cause inflammation in the brain and nerve cell lesions,” says Roland Martin, Director of the Clinical Research Priority Program Multiple Sclerosis at UZH.Novel MS drugs attack B cellsUntil recently, MS research had mainly focused on T cells, or T helper cells. They are the immune system’s “guardians”, which for example sound the alarm if the organism is infected with a virus or bacteria. In about one in a 1,000 people, the cells’ ability to distinguish between the body’s own and foreign structures becomes disturbed. The effect of this is that the misguided T cells start to attack the body’s own nerve tissue – the onset of MS. However, the T cells aren’t the sole cause of this. “A class of MS drugs called Rituximab and Ocrelizumab led us to believe that B cells also played an important part in the pathogenesis of the disease,” explains Roland Martin. These drugs eliminate B cells, which very effectively inhibits inflammation of the brain and flare-ups in patients.Related StoriesResearch team to create new technology for tackling concussionStudy provides new insight into longitudinal decline in brain network integrity associated with agingDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustB cells’ “complicity” revealedThe researchers established the role of B cells by using an experimental in-vitro system that allowed blood samples to be analyzed. The blood of people with MS revealed increased levels of activation and cellular division among those T cells attacking the body’s myelin sheaths that surround nerve cells. This was caused by B cells interacting with the T cells. When the B cells were eliminated, the researchers found that it very effectively inhibited the proliferation of T cells. “This means that we can now explain the previously unclear mechanism of these MS drugs,” says Roland Martin.Activated T cells migrate to the brainMoreover, the team also discovered that the activated T cells in the blood notably included those that also occur in the brain in MS patients during flare-ups of the disease. It is suspected that they cause the inflammation. Further studies showed that these T cells recognize the structures of a protein that is produced by the B cells as well as nerve cells in the brain. After being activated in the peripheral blood, the T cells migrate to the brain, where they destroy nerve tissue. “Our findings not only explain how new MS drugs take effect, but also pave the way for novel approaches in basic research and therapy for MS,” concludes Roland Martin.